张金凤，副教授/特别研究员（博士生导师）

联系方式  E-mail：[email protected]

招生方向：生物学/生物医学工程/生物与医药

欢迎具有化学、药学、材料学、生物学、医学背景，具有探索求新精神和科研兴趣的同学加入课题组！

1. 个人简介

       张金凤，中共党员，湖南湘潭人，博士，bet365 スロット おすすめ副教授/特别研究员，博士生导师。研究领域为高效低毒全活性纳米药物的制备及其生物医学应用研究。在ACS Nano, Nano Lett., Adv. Funct. Mater., Angew. Chem. Int. Ed., Biomaterials, Small, Theranostics, ACS Appl. Mater. Interfaces等国际著名学术期刊上发表SCI论文50余篇，总引用1800余次（H index = 25）；其中以通讯或第一作者发表论文28篇（单篇平均IF>9），其中5篇为编辑推荐封面文章，影响因子>10的论文11篇，入选Wiley期刊 TOP Downloaded Paper（2019）。目前申请/授权国家发明专利8项（已获转让2项）、授权美国发明专利1项，编写英文专著章节1部；主持国家自然科学基金、北京市自然科学基金等项目5项，入选北京市科协青年人才托举工程项目（2021）；曾获香港城市大学最佳博士毕业论文奖、周亦卿研究生院奖、CityU卓越学术研究一等奖、杰出学术成就奖、北京市优秀毕业生等多个奖项。受邀担任国际期刊Frontiers in Chemistry、Journal of Nanoelectronics and Optoelectronics客座编辑；长期担任ACS Nano, Adv. Funct. Mater., Biomaterials, ACS Appl. Mater. Inter., Adv. Healthc. Mater., Theranostics, Mol. Pharm.及Wiley book等三十余个国际知名期刊审稿人。

2. 教育经历

2014.07-2017.07     哲学博士，生物与化学系，香港城市大学, （导师：Prof. Chun-Sing LEE）               

2010.09-2013.06     理学硕士（推荐免试），有机化学，中科院理化技术研究所（导师：张晓宏教授）

2006.09-2010.06     工学学士，化学工程与工艺，中国矿业大学 (北京)

3. 工作经历

2018.09-至今           副教授/特别研究员，bet365 スロット おすすめ，北京理工大学

2017.08-2018.08     高级副研究员/博士后研究员，化学系，香港城市大学

2013.12-2014.06     研究助理，物理与材料科学系，香港城市大学     

2013.07-2013.12     研究助理，中国科学院理化技术研究所

4. 获奖及荣誉 

（1）2021年，北京理工大学第十五届我爱我师十大“我最喜爱老师”称号

（2）2020年，北京理工大学求是书院“优秀学育导师组长”（即优秀班主任）

（3）2017年，香港城市大学优秀毕业论文奖（全系唯一）

（4）2017年，第七届ChinaNANO国际会议最佳墙报奖

（5）2016 & 2015年，香港城市大学杰出学术成就奖

（6）2015年，香港城市大学周亦卿研究生院奖（全系唯一）

（7）2015年，第一届ICOBAN纳米材料生物医学应用国际会议最佳墙报奖

（8）2015年，香港城市大学学术研究卓越一等奖（全系唯一）

（9）2011年，中国科学院研究生院三好学生

（10）2010年，北京市优秀毕业生

5. 研究领域及方向

（1）基于超分子自组装的全活性纳米药物及纳米诊疗剂的制备及其结构、性能调控；

（2）基于生物光子学的纳米诊疗剂的设计及其生物医学应用，涉及近红外/双光子成像、荧光寿命成像、光声成像及光动力、光热治疗等多种方式，实现对重大疾病的精准诊疗；

（3）基于联合治疗模式（包括化疗、光疗、铁死亡、基因治疗、免疫治疗或联合治疗等）的纳米药物递送系统的设计及其用于不同疾病的诊疗研究，涉及癌症、动脉粥样硬化、神经退行性疾病、炎症性肠病、急性肝衰竭（肝再生）等疾病，进一步推动高效低毒的纳米药物递送系统的临床转化。

6. 主持或主要参与基金项目

（1）国家自然科学基金青年项目，32001010，pH响应的核-壳型全活性纳米药物的构建及其抗肿瘤协同治疗，24万元，2021.01-2023.12，在研，课题负责人；

（2）北京市自然科学基金青年项目，2214078，光、氧双非依赖型多重活性氧纳米发生器用于乏氧肿瘤高效治疗，10万元，2021.01-2022.12，在研，课题负责人。

（3）北京理工大学青年学者研究基金，高效仿生无载体纳米药物的构建及其生物医学应用研究，2018.09-2021.09，60万元，在研，课题负责人；

（4）国家自然科学基金重大科学计划项目培育项目，91859123，活体微循环的微米级分辨动态分子影像技术与恶性实体瘤早期诊断， 2019.01-2021.12，30/100万元，在研，子课题负责人；

（5）香港创新科技署创新及科技基金，ITS/372/17，Preparation of Self-assembled Nanodrugs (SANDs) by an Ice-template Assisted Method，2018.02-2019.07，140万港币，已结题，主要参与人；

（6）香港城市大学教育资助委员会应用研究资助基金，9667160，Self-Assembly of TADF-Based Organic Nanostructures for Cancer Photodynamic Therapy，2018.03-2019.08，25万港币，已结题，主要参与人；

（7）香港城市大学教育资助委员会基金，9610352，Self-Carried Drug Nanoparticles for Cancer Therapy，2016.01-2017.12，30万港币，已结题，主要参与人。

7. 代表性论文及专利（影响因子IF为2020年公布数据）

（a）第一或通讯（含共同）作者期刊论文列表

（1）Xiao Cui^#, Guihong Lu^#, Fang Fang, Yuan Xiong, Shuang Tian, Yingpeng Wan, Yafang Xiao, Dong Shen, Hui Wang, Jinfeng Zhang*, Chun-Sing Lee*, Iron Self-Boosting Polymer Nanoenzyme for Low-Temperature Photothermal-Enhanced Ferrotherapy. ACS Appl. Mater. Interfaces 2021, 13, just accepted. (IF: 8.758, 一区TOP)

（2）Yinfeng Zhang^#, Fang Fang^#, Yongjie Chen^#, Min Li, Li Li, Wenyue Li*, Jinfeng Zhang*, Hollow Mesoporous Polyaniline Nanoparticles with High Drug Payload and Robust Photothermal Capability for Cancer Combination Therapy. Chin. J. Chem. Eng. 2021, 29, just accepted. (IF: 2.627, 二区)

（3）Xiaozhen Li^#, Fang Fang^#, Bo Sun, Chao Yin, Jihua Tan, Yingpeng Wan, Jinfeng Zhang*, Pengfei Sun, Quli Fan, Pengfei Wang, Shengliang Li*, Chun-Sing Lee*, Near-Infrared Small Molecule Coupled With Rigidness and Flexibility For High-Performance Multimodal Imaging-Guided Photodynamic and Photothermal Synergistic Therapy. Nanoscale Horiz. 2021, 6, 177-185. (IF: 9.927, 一区TOP)

（4）Li Huang, Shaojing Zhao, Fang Fang, Ting Xu, Minhuan Lan*, Jinfeng Zhang*, Advances and Perspectives in Carrier-free Nanodrugs for Cancer Chemo-Monotherapy and Combination Therapy. Biomaterials 2021, 268, 120557. (IF: 10.273, 一区TOP)

（5）Xiao Cui^#, Guihong Lu^#, Shengzhi Dong, Shengliang Li*, Yafang Xiao, Jinfeng Zhang*, Yanhong Liu, Xiangmin Meng, Feng Li*, Chun-Sing Lee*, Stable π-Radical Nanoparticles as Versatile Photosensitizer for Effective Hypoxia-Overcoming Photodynamic Therapy. Mater. Horiz. 2021, 8, 571-576. (IF: 12.319, 一区TOP)

（6）Yinfeng Zhang, Fang Fang, Li Li, Jinfeng Zhang*, Self-Assembled Organic Nanomaterials for Drug Delivery, Bioimaging, and Cancer Therapy. ACS Biomater. Sci. Eng. 2020, 6, 4816−4833. (IF: 4.152, 二区)

（7）Fang Fang^#, Dongxu Zhao^#, Yinfeng Zhang, Min Li, Jun Ye*, Jinfeng Zhang*, Europium-Doped Nanoparticles for Cellular Luminescence Lifetime Imaging via Multiple Manipulations of Aggregation State. ACS Appl. Bio Mater. 2020, 3, 5103−5110. (Featured on the Front Cover page)

（8）Yingpeng Wan^#, Guihong Lu^#, Wei-Chih Wei^#, Yi-Hsuan Huang, Shengliang Li*, Jia-Xiong Chen, Xiao Cui, Ya-Fang Xiao, Xiaozhen Li, Yanhong Liu, Xiang-Min Meng, Pengfei Wang, Hai-Yan Xie, Jinfeng Zhang*, Ken-Tsung Wong*, Chun-Sing Lee*. Stable Organic Photosensitizer Nanoparticles with Absorption Peak beyond 800 Nanometers and High Reactive Oxygen Species Yield for Multimodality Phototheranostics. ACS Nano 2020, 14, 9917-992. (IF: 14.588, 一区TOP)

（9）Yinfeng Zhang, Li Li, Jinfeng Zhang*, Curcumin in Antidepressant Treatments: An Overview of Potential Mechanisms, Pre-Clinical/Clinical Trials and Ongoing Challenges. Basic Clin. Pharmacol. Toxicol. 2020, 127, 243-253. (IF: 2.651, 三区)

（10）Fang Fang, Min Li, Jinfeng Zhang*, Chun-Sing Lee*, Different Strategies for Organic Nanoparticle Preparation in Biomedicine. ACS Materials Lett. 2020, 2, 531−549. (即时IF:  8.1081, 一区TOP)

（11）Jingyi Liu^#, Chao Liu^#, Jinfeng Zhang^#, Yunming Zhang, Keyin Liu, Ju-Xian Song, Sravan Gopalkrishnashetty Sreenivasmurthy, Ziying wang, Yesi Shi, Chengchao Chu, Yang Zhang, Caisheng Wu, Xianhua Deng, Xingyang Liu, Jing Song, Rongqiang Zhuang, Shuqiong Huang, Pengfei Zhang, Min Li*, Lei Wen*, Yunwu Zhang, and Gang Liu*, A Self-Assembled α-Synuclein Nanoscavenger for Parkinson’s Disease. ACS Nano 2020, 14, 1533-1549. (IF: 14.588, 一区TOP)

（12）Xiao Cui, Jinfeng Zhang*, Yingpeng Wan, Fang Fang, Rui Chen, Dong Shen, Zhongming Huang, Shuang Tian, Yafang Xiao, Xiaozhen Li, Jipsa Chelora, Yanhong Liu, Wenjun Zhang*, Chun-Sing Lee*, Dual Fenton Catalytic Nanoreactor for Integrative Type‑I and Type-II Photodynamic Therapy Against Hypoxic Cancer Cells. ACS Appl. Bio Mater. 2019, 2, 3854-3860.

（13）Yingpeng Wan^#, Guihong Lu^#, Jinfeng Zhang*, Ziying Wang, Xiaozhen Li, Rui Chen, Xiao Cui, Zhongming Huang, Yafang Xiao, Jipsa Chelora, Wenjun Zhang, Yanhong Liu, Min Li, Hai-Yan Xie, Chun-Sing Lee*, A Biocompatible Free Radical Nanogenerator with Real-Time Monitoring Capability for High Performance Sequential Hypoxic Tumor Therapy. Adv. Funct. Mater. 2019, 29, 1903436. (Featured on the Front Cover page, IF: 16.836, 一区TOP)

（14）Jipsa Chelora, Jinfeng Zhang*, Yingpeng Wan, Xiao Cui, Junfang Zhao, Xiang-Min Meng, Pengfei Wang, Chun-Sing Lee*. Plant Derived Single-Molecule based Nanotheranostic for Photo-Enhanced Chemotherapy and Ferroptotic-Like Cancer Cell Death. ACS Appl. Bio Mater. 2019, 2, 2643-2649.

（15）Jinfeng Zhang, Fang Fang, Bin Liu, Ji-Hua Tan, Wen-Cheng Chen, Zelin Zhu, Yi Yuan, Yingpeng Wan, Xiao Cui, Shengliang Li*, Qing-Xiao Tong, Junfang Zhao, Xiang-Min Meng, and Chun-Sing Lee*. Intrinsically Cancer-Mitochondria-Targeted Thermally Activated Delayed Fluorescence Nanoparticles for Two-Photon-Activated Fluorescence Imaging and Photodynamic Therapy. ACS Appl. Mater. Interfaces 2019, 11, 41051-41061. (Featured on the Front Cover page, IF: 8.758, 一区TOP)

（16）Jinfeng Zhang, Weidong Nie, Rui Chen, Jipsa Chelora, Yingpeng Wan, Xiao Cui, Xiaohong Zhang*, Wenjun Zhang, Xianfeng Chen, Hai-Yan Xie, and Chun-Sing Lee*. Green Mass Production of Pure Nanodrugs via an Ice-Template-Assisted Strategy. Nano Lett. 2019, 19, 2, 658-665. (Featured on the Front Cover page, IF: 11.238, 一区TOP)

（17）Jinfeng Zhang, Jing Chen, Jingkun Ren, Weisheng Guo, Xianlei Li, Rui Chen, Jipsa Chelora, Xiao Cui, Yingpeng Wan, Xing-Jie Liang*, Yuying Hao*, Chun-Sing Lee*. Biocompatible Semiconducting Polymer Nanoparticles as Robust Photoacoustic and Photothermal Agents Revealing the Effects of Chemical Structure on High Photothermal Conversion Efficiency. Biomaterials 2018, 181, 92-102. (IF: 10.273, 一区TOP)

（18）Jinfeng Zhang, Jun Zhang, Wenyue Li, Rui Chen, Zhenyu Zhang, Wenjun Zhang, Yongbing Tang, Xiaoyuan Chen, Gang Liu*, Chun-Sing Lee*. Degradable Hollow Mesoporous Silicon/Carbon Nanoparticles for Imaging-Guided Highly Effective Chemo-Thermal Tumor Therapy in Vitro and in Vivo. Theranostics 2017, 7, 3007-3020. (IF: 8.579, 一区TOP)

（19）Jinfeng Zhang, Caixia Yang, Rui Zhang, Rui Chen, Zhenyu Zhang, Wenjun Zhang, Shih-Hao Peng, Xiaoyuan Chen, Gang Liu*, Chain-Shu Hsu,* Chun-Sing Lee*. Biocompatible D-A Semiconducting Polymer Nanoparticle with Light-Harvesting Unit for Highly Effective Photoacoustic Imaging Guided Photothermal Therapy. Adv. Funct. Mater. 2017, 27, 1605094. (IF: 16.836, 一区TOP)

（20）Jinfeng Zhang^#, Wencheng Chen^#, Rui Chen, Xiao-Ke Liu, Yuan Xiong, Stephen V. Kershaw, Andrey L. Rogach, Chihaya Adachi*, Xiaohong Zhang, Chun-Sing Lee. Organic Nanostructures of Thermally Activated Delayed Fluorescent Emitters with Enhanced Intersystem Crossing as Novel Metal-Free Photosensitizers. Chem. Commun. 2016, 52, 11744-11747. (Featured on the Front Cover page, IF: 5.996, 二区TOP)

（21）Jinfeng Zhang, Wencheng Chen, Sergii Kalytchuk, King Fai Li, Rui Chen, Chihaya Adachi*, Zhan Chen, Andrey L. Rogach, Guangyu Zhu, Peter K. N. Yu, Wenjun Zhang, Kok Wai Cheah, Xiaohong Zhang*, Chun-Sing Lee*. Self-Assembly of Electron Donor-Acceptor Based Carbazole Derivatives: Novel Fluorescent Organic Nanoprobes for Both One-Photon and Two-Photon Cellular Imaging. ACS Appl. Mater. Interfaces 2016, 8, 11355-11365. (IF: 8.758, 一区TOP)

（22）Jinfeng Zhang, Rui Chen, Zelin Zhu, Chihaya Adachi*, Xiaohong Zhang, Chun-Sing Lee*. Highly Stable Near-Infrared Fluorescent Organic Nanoparticles with A Large Stokes Shift for Noninvasive Long-Term Cellular Imaging. ACS Appl. Mater. Interfaces 2015, 7, 26266-26274. (IF: 8.758, 一区TOP)

（23）Jinfeng Zhang^#, Yu-Chuan Liang^#, Xudong Lin, Xiaoyue Zhu, Li Yan, Shengliang Li, Xia Yang, Guangyu Zhu, Andrey L. Rogach, Peter K. N. Yu, Peng Shi, Lung-Chen Tu, Chia-Ching Chang*, Xiaohong Zhang*, Xianfeng Chen, Wenjun Zhang, Chun-Sing Lee*. Self-Monitoring and Self-Delivery of Photosensitizer-Doped Nanoparticles for Highly Effective Combination Cancer Therapy in Vitro and in Vivo. ACS Nano 2015, 9, 9741-9756. (IF: 14.588, 一区TOP)

（24）Jinfeng Zhang^#, Shengliang Li^#, Fei-Fei An, Juan Liu, Shubin Jin, Jin-Chao Zhang, Paul C. Wang, Xiaohong Zhang*, Chun-Sing Lee*, Xing-Jie Liang*. Self-Carried Curcumin Nanoparticles for in Vitro and in Vivo Cancer Therapy with Real-Time Monitoring of Drug Release. Nanoscale 2015, 7, 13503-13510. (IF: 6.895, 一区TOP)

（25）Minhuan Lan^#, Jinfeng Zhang^#, Xiaoyue Zhu, Pengfei Wang*, Xianfeng Chen*, Chun-Sing Lee, Wenjun Zhang*. Highly Stable Organic Fluorescent Nanorods for Living Cell Imaging. Nano Res. 2015, 8, 2380-2389. (IF: 8.183, 一区TOP)

（26）Jinfeng Zhang, Yanan Li, Fei-Fei An, Xiaohong Zhang*, Xianfeng Chen, Chun-Sing Lee*. Preparation and Size Control of Sub-100 nm Pure Nanodrugs. Nano Lett. 2015, 15, 313-318. (IF: 11.238, 一区TOP)

（27）Li Yan^#, Jinfeng Zhang^#, Chun-Sing Lee, Xianfeng Chen*. Micro- and Nanotechnologies for Intracellular Delivery. Small 2014, 10, 4487-4504. (IF: 11.459, 一区TOP)

（28）Jinfeng Zhang, Feifei An, Yanan Li, Caijun Zheng, Yinlong Yang, Xiujuan Zhang*, Xiaohong Zhang*. Simultaneous Enhanced Diagnosis and Photodynamic Therapy of Photosensitizer-Doped Perylene Nanoparticles via Doping, Fluorescence Resonance Energy Transfer, and Antenna Effect. Chem. Commun. 2013, 49, 8072-8074. (IF: 5.996, 二区TOP)

（b）已授权或已转让专利

（1）Chun-Sing Lee, Xiaohong Zhang, Jinfeng Zhang, Fu-Lung Wong. Nanoparticles, Method of Preparing the Same and Their Use. US Patent, Granted, US10085942B2.

（2）梁兴杰，张晓宏，李盛亮，张金凤，曹伟鹏，李峰，一种疏水性药物纳米颗粒、其制备方法和应用。专利授权公告号：CN103550776B。

（3）张晓宏，张金凤，安菲菲，具有荧光共振能量转移及天线效应的用于光动力治疗的光敏剂掺杂纳米粒子的制备方法。专利授权公告号：CN103212074 B。

（4）张晓宏，张金凤，一种冰模板法制备疏水性药物纳米颗粒的方法。专利授权公告号：CN103191019 B。

（5）刘刚，刘静怡，文磊，张金凤，一种用于防治早期神经退行性疾病的鼻腔纳米自噬诱导剂及其制备方法。专利申请号：201910019951 .6，已转让。

（6）刘刚，刘静怡，文磊，张金凤，张阳，一种壳寡糖修饰的自携式无载体鼻腔纳米。专利申请号：201910019559 .1，已转让。

（7）谢海燕，武广昊，赵倩茹，张金凤，一种主动趋炎抗炎工程化外泌体及其制备方法。专利授权公告号：CN110917173B。